Assessment methods for aspirin-mediated platelet antiaggregation in type 2 diabetic patients: degree of correlation between 2 point-of-care methods.
| Autor: | Cubero Gómez JM; Department of Cardiology, Hospital Universitario Virgen del Rocio, Seville, Spain; and Departments of †Internal Medicine, ‡Investigation, and §Cardiology, Hospital Universitario Virgen de Valme, Seville, Spain., Navarro Puerto MA, Acosta Martínez J, De Mier Barragán MI, Pérez Santigosa PL, Sánchez Burguillos F, Molano Casimiro F, Pastor Torres L |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2014 Jul; Vol. 64 (1), pp. 16-20. |
| DOI: | 10.1097/FJC.0000000000000084 |
| Abstrakt: | Aims: Impaired response to antiplatelet therapy in diabetic patients results in a higher incidence of drug-eluting stent thrombosis. This study determined the prevalence of high on-aspirin (AS) platelet reactivity in type 2 diabetic patients treated with percutaneous coronary intervention (PCI) using the VerifyNow Aspirin Assay (VN) and platelet function analyzer PFA-100 (PFA-100) and analyzed the correlation between both methods. Methods: Type 2 diabetic patients (100) with non-ST-elevation acute coronary syndrome who underwent PCI and Xience V drug-eluting stent implantation were included in this study. After PCI, platelet antiaggregation mediated by acetylsalicylic acid was assessed by VN and PFA-100. The degree of correlation and concordance was then determined. Results: When assayed with VN, 7% of the patients were nonresponders to aspirin (aspirin reaction units >550), and when assayed with PFA-10, 41% were nonresponders (closure time <193 seconds). Of the patients, 4% were nonresponders to aspirin according to VN but were sensitive to aspirin according to PFA-100, and 38% were sensitive to aspirin according to VN and nonresponders according to PFA-100. Overall, 55% of the patients were aspirin-sensitive in both methods. The Spearman's coefficient between VN and PFA-100 results was r = 0.09 (P = 0.35). The kappa index value was 0.0062 (P = 0.91). Conclusions: There is no concordance or correlation between the VN and PFA-100 results. Therefore, the use of these analyses should be restricted to clinical research, which limits its application in clinical practice. |
| Databáze: | MEDLINE |
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