| Autor: |
Crabbe JC; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Metten P; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Huang LC; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Schlumbohm JP; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Spence SE; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Barkley-Levenson AM; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Finn DA; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA., Rhodes JS; Neuroscience Program, The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Cameron AJ; Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. |
| Abstrakt: |
Individual mice differ in the dose of ethanol they will ingest voluntarily when it is offered during limited access periods in the circadian dark, a phenotype called drinking in the dark (DID). Substantial genetic variation in DID has been reported across a few standard inbred mouse strains, and a line of High Drinking in the Dark (HDID) mice has been established through selective breeding on the blood ethanol concentration (BEC) they attain at the end of a drinking session. Here, we report ethanol DID data for 23 inbred mouse strains, including 11 not previously reported, corroborating the genetic contributions to this trait. We also report data on a different ethanol drinking trait, the increased intake seen after multiple cycles of chronic intermittent exposure to ethanol vapor (CIE). Drinking escalated significantly during ethanol withdrawal. However, HDID mice and their HS controls showed equivalent escalation during withdrawal, demonstrating that withdrawal-associated drinking escalation is not a clear genetic correlate of selection on DID. Across inbred strains, DID is substantially genetically correlated with previously-published two-bottle ethanol preference drinking data assessed under conditions of continuous ethanol access. Although inbred strain data for withdrawal-associated drinking are not available, the current pattern of results suggests that withdrawal-associated drinking is genetically distinct from DID, while genetic contributions to DID and two-bottle preference drinking are substantially similar. |
