Plasma cytokine concentrations in dogs with a congenital portosystemic shunt.

Autor: Kilpatrick S; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Gow AG; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom; Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Foale RD; Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire CB8 0UH, United Kingdom., Tappin SW; Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire CB8 0UH, United Kingdom., Carruthers H; Tay Valley Veterinary Centre, Perth PH2 0PA, United Kingdom., Reed N; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Yool DA; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Woods S; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Marques AI; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom., Jalan R; UCL Institute of Hepatology, Royal Free Hospital, Upper Third Floor, UCL Medical School, Pond Street, London NW3 2QG, United Kingdom., Mellanby RJ; Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom; Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom. Electronic address: Richard.mellanby@ed.ac.uk.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2014 Apr; Vol. 200 (1), pp. 197-9. Date of Electronic Publication: 2014 Jan 17.
DOI: 10.1016/j.tvjl.2014.01.007
Abstrakt: Congenital portosystemic shunts (cPSS) are a well-recognised vascular anomaly in dogs. Recent studies have shown an association between inflammation and hepatic encephalopathy (HE), which is a common clinical syndrome in dogs with a cPSS. Pro-inflammatory cytokines such as interleukin (IL)-6 and tumour necrosis factor (TNF)-α are frequently increased in the plasma of human patients with liver disease and have been implicated in the development of HE. In the current study, plasma concentrations of IL-2, IL-6, IL-8 and TNF-α were measured using a multiplex electrochemiluminescence immunoassay in 36 dogs with a cPSS and compared to 25 healthy dogs. There were no significant differences in plasma IL-2, IL-8 and TNF-α concentrations between the two groups; however, plasma concentrations of IL-6 were significantly higher in dogs with a cPSS compared to healthy dogs (P=0.02).
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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