| Autor: |
Sini V, Menghi A, Cursano MC, Mandolini PL, Lanza R |
| Jazyk: |
angličtina |
| Zdroj: |
Tumori [Tumori] 2013 Nov-Dec; Vol. 99 (6), pp. 273e-7e. |
| DOI: |
10.1700/1390.15467 |
| Abstrakt: |
This report describes a case of ab initio metastatic HER2-positive breast cancer in a very young patient. The onset of breast cancer at such a young age is uncommon and could delay the diagnosis with unquestionable impact on the prognosis. Unfortunately, the patient experienced cerebral progression during first-line treatment. Indeed, brain metastases occur in about one-third of HER2-positive metastatic breast cancer patients during trastuzumab-based treatment. The small molecule lapatinib is active in established cerebral disease, and we report a complete brain response longer than expected, thanks to a well-tolerated, orally administered combination of lapatinib and capecitabine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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