Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis.

Autor: Hong SB; Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Zalesky A; Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health., Fornito A; Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health; Monash Clinical and Imaging Neuroscience, School of Psychology and Psychiatry & Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia., Park S; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Yang YH; Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan., Park MH; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Song IC; Department of Radiology, Seoul National University Hospital., Sohn CH; Department of Radiology, Seoul National University Hospital., Shin MS; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Kim BN; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Cho SC; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Han DH; Department of Psychiatry, Chung Ang University, College of Medicine., Cheong JH; Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea., Kim JW; Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address: adore412@paran.com.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2014 Oct 15; Vol. 76 (8), pp. 656-63. Date of Electronic Publication: 2014 Jan 08.
DOI: 10.1016/j.biopsych.2013.12.013
Abstrakt: Background: Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturbances in ADHD.
Methods: Using diffusion tensor imaging, whole-brain tractography, and an imaging connectomics approach, we characterized altered white matter connectivity in 71 children and adolescents with ADHD compared with 26 healthy control subjects. White matter differences were further delineated between patients with (n = 40) and without (n = 26) the predominantly hyperactive/impulsive subtype of ADHD.
Results: A significant network comprising 25 distinct fiber bundles linking 23 different brain regions spanning frontal, striatal, and cerebellar brain regions showed altered white matter structure in ADHD patients (p < .05, family-wise error-corrected). Moreover, fractional anisotropy in some of these fiber bundles correlated with attentional disturbances. Attention-deficit/hyperactivity disorder subtypes were differentiated by a right-lateralized network (p < .05, family-wise error-corrected) predominantly linking frontal, cingulate, and supplementary motor areas. Fractional anisotropy in this network was also correlated with continuous performance test scores.
Conclusions: Using an unbiased, whole-brain, data-driven approach, we demonstrated abnormal white matter connectivity in ADHD. The correlations observed with measures of attentional performance underscore the functional importance of these connectomic disturbances for the clinical phenotype of ADHD. A distributed pattern of white matter microstructural integrity separately involving frontal, striatal, and cerebellar brain regions, rather than direct frontostriatal connectivity, appears to be disrupted in children and adolescents with ADHD.
(Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: