| Autor: |
Kikuchi T; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Okamura T; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Wakizaka H; Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Okada M; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Odaka K; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Yui J; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Tsuji AB; Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Fukumura T; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan., Zhang MR; Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. |
| Abstrakt: |
After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood-brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3(-/-) mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after (99m)Tc-ECD administration. |
