Evaluation of alternative rapid thin layer chromatography systems for quality control of technetium-99m radiopharmaceuticals.

Autor: Mang'era K; Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9,; Radiology, Faculty of Medicine, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, Canada R3T 2N2; Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5. Electronic address: kmangera@hsc.mb.ca., Wong D; Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9,; Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5., Douglas D; Radiology, Faculty of Medicine, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, Canada R3T 2N2., Franz K; Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9., Biru T; Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2014 Apr; Vol. 86, pp. 57-62. Date of Electronic Publication: 2014 Jan 08.
DOI: 10.1016/j.apradiso.2013.12.016
Abstrakt: Whatman 3MM™ and Tec-Control™ systems were evaluated as ITLC-SG alternatives for 99mTc-radiopharmaceuticals. They compare well in accuracy and reproducibility, and are faster and more convenient than ITLC-SG. Tec-Control™ radiochemical purity values for 99mTc-sestamibi were more conservative than ITLC-SG. Full solvent migration was not reproduced for 99mTc-tetrofosmin in Tec-Control™, and for this Whatman 3MM™ is preferred. Developing times were 10-15 min, 7-9 min and ~1min for ITLC-SG, Whatman 3MM™ and Tec-Control™, respectively. Overall, Tec-Control™ strips are preferred due to speed and ease of use.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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