[Mechanism of postextrasystolic potentiation of the myocardium].

Autor: Markhasin VS, Tsyv'ian PB, Artem'eva OG, Mil'shteĭn GN, Solov'eva OE
Jazyk: ruština
Zdroj: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova [Fiziol Zh SSSR Im I M Sechenova] 1987 Oct; Vol. 73 (10), pp. 1339-44.
Abstrakt: Combined effects of poststimulation and postextrasystolic potentiation (PESP) were studied in the rat papillary muscles. The constant PESP augmentation of isometric force triggered by extrasystolic stimulus was shown for 2-8 poststimulatory potentiated contractions. The PESP was not dependent upon the Ca2+ concentration within the 0.5-1.2 mM range. The findings corroborate the postulate that the PESP in cardiomyocytes is associated with special Ca2+ store which is triggered by two APs: regular and extrasystolic ones.
Databáze: MEDLINE