Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis.

Autor:	Acar GR; Department of Cardiology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. gurkandracar@hotmail.com., Akkoyun M; Department of Cardiology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey., Nacar AB; Department of Cardiology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey., Dirnak I; Department of Cardiology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey., Yıldırım Çetin G; Department of Rheumatology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey., Nur Yıldırım M; Department of Cardiology, Necip Fazıl State Hospital, Kahramanmaraş, Turkey., Zencir C; Department of Cardiology, Necip Fazıl State Hospital, Kahramanmaraş, Turkey., Karaman K; Department of Cardiology, Necip Fazıl State Hospital, Kahramanmaraş, Turkey., Cetin M; Department of Cardiology, Necip Fazıl State Hospital, Kahramanmaraş, Turkey., Sayarlıoğlu M; Department of Rheumatology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey.
Jazyk:	angličtina
Zdroj:	Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir [Turk Kardiyol Dern Ars] 2014 Jan; Vol. 42 (1), pp. 29-34.
DOI:	10.5543/tkda.2014.52959
Abstrakt:	Objectives: Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using the Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis (RA), and to assess the relation with inflammation. Study Design: Ninety-six patients (72 females, 24 males; mean age 43.8±11.8 years) with RA and 50 controls (35 females, 15 males; mean age 44.2±11.1 years) were included. From the 12-lead electrocardiogram, Tp-e interval and Tp-e/QT ratio were measured. Blood samples were taken for erythrocyte sedimentation rate (ESR) and plasma levels of C-reactive protein (CRP). These parameters were compared between groups. The relationship between ventricular repolarization and inflammation was assessed by Pearson correlation coefficients. Results: Tp-e interval and Tp-e/QT ratio were increased in RA patients compared to the controls (72.6±8.2 vs 66.4±8.5 ms, 0.20±0.02 vs 0.18±0.02; p<0.001 and p<0.001, respectively). The Tp-e interval was significantly correlated with CRP, ESR, and disease activity score (DAS-28) (r=0.56, p<0.001, r=0.57, p<0.001, and r=0.29, p=0.02, respectively). The Tp-e/QT ratio was also correlated with CRP, ESR, and DAS-28 score (r=0.43, p<0.001, r=0.53, p<0.001, and r=0.25, p=0.03, respectively). Conclusion: In RA patients, the increased frequency of ventricular arrhythmias may be explained by increased indexes of ventricular repolarization and their relationship with inflammation.
Databáze:	MEDLINE
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