Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis.

Autor: Baptista MJ; Laboratory of Experimental Hematology, Department of Hematology, Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain., Calpe E; Laboratory of Experimental Hematology, Department of Hematology, Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain., Fernandez E; Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain., Colomo L; Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain., Cardesa-Salzmann TM; Department of Pediatric Oncology, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain., Abrisqueta P; Laboratory of Experimental Hematology, Department of Hematology, Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain., Bosch F; Laboratory of Experimental Hematology, Department of Hematology, Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain. Electronic address: fbosch@vhebron.net., Crespo M; Laboratory of Experimental Hematology, Department of Hematology, Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Leukemia research [Leuk Res] 2014 Apr; Vol. 38 (4), pp. 509-15. Date of Electronic Publication: 2014 Jan 13.
DOI: 10.1016/j.leukres.2014.01.001
Abstrakt: The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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