Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study.
| Autor: | Andrade MC, Oliveira Mde F, Nagao-Dias AT, Coêlho IC, Cândido Dda S, Freitas EC, Coelho HL, Bezerra FS |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2013 Nov-Dec; Vol. 46 (6), pp. 776-8. |
| DOI: | 10.1590/0037-8682-1646-2013 |
| Abstrakt: | Introduction: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. Methods: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. Results: The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. Conclusions: Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients. |
| Databáze: | MEDLINE |
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