Nocturnal hypoxemia in children and adolescents with cystic fibrosis.

Autor:	Ramos RT; Federal University of Bahia School of Medicine, Department of Pediatrics, Salvador, Brazil., Santana MA; Bahia State Referral Center for Cystic Fibrosis, Salvador, Brazil., Almeida Pde C; Federal University of Bahia School of Medicine, Department of Pediatrics, Salvador, Brazil., Machado Ade S Jr; Bahia Foundation for Science Development, Bahia School of Medicine and Public Health, Salvador, Brazil., Araújo-Filho JB; Federal University of Bahia, Collective Health Institute, Salvador, Brazil., Salles C; Federal University of Bahia, School of Medicine, Salvador, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2013 Nov-Dec; Vol. 39 (6), pp. 667-74.
DOI:	10.1590/S1806-37132013000600005
Abstrakt:	Objective: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF). Methods: This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients. Results: The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs = -0.42; p = 0.01), FVC (rs = -0.46; p = 0.01), microarousal index (rs = 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01). Conclusions: In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.
Databáze:	MEDLINE
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