Risk factors associated with death in Brazilian children with severe dengue: a case-control study.

Autor:	Branco Mdos R; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Luna EJ; Departamento de Moléstias Infecciosas e Parasitárias (LIMHC), Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo/SP, Brazil, Universidade de Sa˜o Paulo, Instituto de Medicina Tropical de Sa˜o Paulo, Departamento de Mole´ stias Infecciosas e Parasita´ rias (LIMHC), Sa˜o Paulo/SP, Brazil., Braga Júnior LL; Hospital da Universidade Federal do Maranhão, São Luís/MA, Brazil, Hospital da Universidade Federal do Maranha˜o, Sa˜o Luı´s/MA, Brazil., Oliveira RV; Hospital da Universidade Federal do Maranhão, São Luís/MA, Brazil, Hospital da Universidade Federal do Maranha˜o, Sa˜o Luı´s/MA, Brazil., Rios LT; Hospital da Universidade Federal do Maranhão, São Luís/MA, Brazil, Hospital da Universidade Federal do Maranha˜o, Sa˜o Luı´s/MA, Brazil., Silva Mdo S; Vigilância Epidemiológica Municipal de São Luís, São Luís/MA, Brazil, Vigilância Epidemiológica Municipal de São Luı´s, Sa˜o Luı´s/MA, Brazil., Medeiros MN; Vigilância Epidemiológica Municipal de São Luís, São Luís/MA, Brazil, Vigilância Epidemiológica Municipal de São Luı´s, Sa˜o Luı´s/MA, Brazil., Silva GF; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Nina FC; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Lima TJ; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Brito JA; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Oliveira AC; Departamento de Patologia, Universidade Federal do Maranhão, São Luís/MA, Brazil, Universidade Federal do Maranha˜ o, Departamento de Patologia, Sa˜o Luı´s/MA, Brazil., Pannuti CS; Departamento de Moléstias Infecciosas e Parasitárias (LIMHC), Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo/SP, Brazil, Universidade de Sa˜o Paulo, Instituto de Medicina Tropical de Sa˜o Paulo, Departamento de Mole´ stias Infecciosas e Parasita´ rias (LIMHC), Sa˜o Paulo/SP, Brazil.
Jazyk:	angličtina
Zdroj:	Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2014 Jan; Vol. 69 (1), pp. 55-60.
DOI:	10.6061/clinics/2014(01)08
Abstrakt:	Objective: The purpose of this case-control study was to evaluate risk factors associated with death in children with severe dengue. Methods: The clinical condition of hospitalized patients with severe dengue who died (cases, n = 18) was compared with that of hospitalized patients with severe dengue who survived (controls, n = 77). The inclusion criteria for this study were age under 13 years; hospital admission in São Luis, northeastern Brazil; and laboratory-confirmed diagnosis of dengue. Results: Severe bleeding (hemoptysis), a defining criterion for dengue severity, was the factor most strongly associated with death in our study. We also found that epistaxis and persistent vomiting, both included as warning signs in the World Health Organization (WHO) classification of dengue, were strongly associated with death. No significant association was observed between any of the laboratory findings and death. Conclusions: The finding that epistaxis and persistent vomiting were also associated with death in children with severe dengue was unexpected and deserves to be explored in future studies. Because intensive care units are often limited in resource-poor settings, any information that can help to distinguish patients with severe dengue with a higher risk to progress to death may be crucial.
Databáze:	MEDLINE
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