| Autor: |
do Nascimento PG; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil. georgina.quimica@gmail.com., Lemos TL; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil. tlglemos@yahoo.com.br., Bizerra AM; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil. aylamarcia@yahoo.com.br., Arriaga ÂM; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil., Ferreira DA; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE 60451-970, Brazil. dafufc@yahoo.com.br., Santiago GM; Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza-CE 60430-370, Brazil. gil@ufc.br., Braz-Filho R; Laboratório de Ciências Químicas (LCQUI)-CCT-UENF/PPGQO-DEQUIM-UFRRJ, Campos dos Goytacazes-RJ 28013-602, Brazil. braz@uenf.br., Costa JG; Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Crato-CE 63105-000, Brazil. galberto.martins@gmail.com. |
| Abstrakt: |
Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3β-formyloxy-urs-12-en-28-oic acid at the concentration of 64 μg/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 μg/mL to 8 μg/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity. |
