Correlation of cytokines and inducible nitric oxide synthase expression with prognostic factors in ovarian cancer.

Autor: Martins Filho A; Research Institute of Oncology (Instituto de Pesquisa em Oncologia)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Jammal MP; Research Institute of Oncology (Instituto de Pesquisa em Oncologia)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Côbo Ede C; Discipline of Special Pathology, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Silveira TP; Discipline of Special Pathology, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Adad SJ; Discipline of Special Pathology, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Murta EF; Research Institute of Oncology (Instituto de Pesquisa em Oncologia)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Nomelini RS; Research Institute of Oncology (Instituto de Pesquisa em Oncologia)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil. Electronic address: rosekeila@terra.com.br.
Jazyk: angličtina
Zdroj: Immunology letters [Immunol Lett] 2014 Mar-Apr; Vol. 158 (1-2), pp. 195-9. Date of Electronic Publication: 2014 Jan 18.
DOI: 10.1016/j.imlet.2014.01.005
Abstrakt: The study related the immunohistochemical staining of cytokines (IL2, IL5, IL6, IL8, IL10, and TNF-alpha), and iNOS staining with clinical and pathological parameters of patients with primary ovarian malignancy. We prospectively evaluated 40 patients who underwent surgical treatment in accordance with pre-established criteria and later confirmed diagnosis of ovarian cancer. Immunohistochemistry study for cytokines (IL2, IL5, IL6, IL8, IL10, TNF-alpha) and iNOS was performed. The evaluation of prognostic factors was performed using the Fisher's exact test. The significance level was less than 0.05. Histological grade 1 was significantly correlated with strong intensity for TNF-α (p=0.0028). In addition, early stages showed strong expression intensity of TNF-α, but this was at the limit of significance (p=0.0525). Strong staining immunohistochemical IL5 was related to disease-free survival less than or equal to 24 months, suggesting that a factor of poor prognosis, but there was no statistical significance (p=0.1771). There was no statistical significance in relation at other cytokines studied. Therefore, immunohistochemical staining in strong intensity for TNF-α was related to histological grade 1 and early stages of ovarian cancer in our sample of patients.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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