TREM-1 modulation during early stages of dengue virus infection.

Autor: Ruiz-Pacheco JA; Departamento de Investigaciones Inmunológicas, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, DF, México; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN, México, DF, México., Vivanco-Cid H; Instituto de Investigaciones Médico Biológicas, Universidad Veracruzana, Veracruz, México., Izaguirre-Hernández IY; Instituto de Investigaciones Médico Biológicas, Universidad Veracruzana, Veracruz, México., Estrada-García I; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN, México, DF, México., Arriaga-Pizano L; Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional 'Siglo XXI', IMSS, México, DF, México., Chacón-Salinas R; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN, México, DF, México., Fonseca-Coronado S; Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuatitlán-Izcalli, Estado de México, México., Vaughan G; Departamento de Investigaciones Inmunológicas, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, DF, México., Tovar KR; Departamento de Investigaciones Inmunológicas, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, DF, México., Rivera-Osorio MP; Departamento de Investigaciones Inmunológicas, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, DF, México., Escobar-Gutiérrez A; Departamento de Investigaciones Inmunológicas, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, DF, México. Electronic address: aescobargutierrez@yahoo.com.
Jazyk: angličtina
Zdroj: Immunology letters [Immunol Lett] 2014 Mar-Apr; Vol. 158 (1-2), pp. 183-8. Date of Electronic Publication: 2014 Jan 18.
DOI: 10.1016/j.imlet.2014.01.003
Abstrakt: Uncontrolled and intricate production of inflammatory factors is the characteristic feature of dengue infection. The triggering receptor expressed in myeloid cells-1 (TREM-1), expressed on the surface of monocytes and neutrophils, is capable of enhancing and regulating the inflammatory response via the production of different mediators in bacterial and viral infections. Here, both the expression of TREM-1 on human monocytes and neutrophils from peripheral blood of dengue infected individuals, as well as the levels of the soluble form of TREM-1 (sTREM-1) in the sera of these patients were compared against healthy controls. A significant reduction of TREM-1 expression was observed in neutrophils during the first days of infection, followed by a gradual recovery throughout the course of infection. Also, sera from DENV-infected patients exhibited significantly higher sTREM-1 levels than healthy individuals. The difference was more pronounced during the first 5 days after the onset of symptoms. These findings highlight the dynamic process of TREM-1 expression during DENV infection. We hypothesized that increment of free sTREM-1 could be a compensatory mechanism aiming to counteract the inflammatory process elicited during DENV infection.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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