| Autor: |
Cheng RK; Institute of Molecular and Cellular Biology, , A*STAR, 61 Biopolis Drive, #08-13 Proteos, Singapore 138673, Singapore., Jesuthasan SJ, Penney TB |
| Jazyk: |
angličtina |
| Zdroj: |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2014 Jan 20; Vol. 369 (1637), pp. 20120462. Date of Electronic Publication: 2014 Jan 20 (Print Publication: 2014). |
| DOI: |
10.1098/rstb.2012.0462 |
| Abstrakt: |
The rise of zebrafish as a neuroscience research model organism, in conjunction with recent progress in single-cell resolution whole-brain imaging of larval zebrafish, opens a new window of opportunity for research on interval timing. In this article, we review zebrafish neuroanatomy and neuromodulatory systems, with particular focus on identifying homologies between the zebrafish forebrain and the mammalian forebrain. The neuroanatomical and neurochemical basis of interval timing is summarized with emphasis on the potential of using zebrafish to reveal the neural circuits for interval timing. The behavioural repertoire of larval zebrafish is reviewed and we demonstrate that larval zebrafish are capable of expecting a stimulus at a precise time point with minimal training. In conclusion, we propose that interval timing research using zebrafish and whole-brain calcium imaging at single-cell resolution will contribute to our understanding of how timing and time perception originate in the vertebrate brain from the level of single cells to circuits. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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