[Treatment for acute promyelocytic leukemia during pregnancy].

Autor:	Troitskaia VV, Parovichnikova EN, Sokolov AN, Kokhno AV, Makhinia SA, Galstian GM, Konstantinova TS, Mazurok LA, Goriachok IG, Korobkin AV, Liubshenko MA, Latyshkevich OA, Zvereva AV, Kurtser MA, Savchenko VG
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2013; Vol. 85 (10), pp. 56-63.
Abstrakt:	Aim: To study the experience in managing patients with acute promyelocytic leukemia (APL) diagnosed in different periods of pregnancy. Subjects and Methods: Nine women with APL were treated in 1998-2013. When APL was diagnosed in the first trimester of pregnancy, the latter was terminated (n = 1); when its diagnosis was made in the second trimester, chemotherapy (CT) followed by delivery (D) was performed (n = 3); when it was done in the third trimester, D followed by CT was done in relation to gestational age (n = 2) or these were performed at a later gestational age (n = 1). APL was treated in 5 and 1 patients according to the AIDA protocol and the 7+3 plus ATRA one, respectively. Results: All the patients with APL achieved remission after the first cycle of induction CT; 5 of the 6 patients did at the moment of delivery; one patient underwent emergency delivery during cytopenia after the cycle. The gestational age at delivery after CT was 34 (34-40) weeks. Spontaneous term labor occurred in 2 patients at an obstetric hospital. Cesarean section was made in 4 of the 6 patients. All babies were born alive, healthy, and without developmental abnormalities. Their age at the time of analyzing the results was 2.5 months to 15 years. Four of the 9 patients are presently alive. Late recurrences occurred in 3 (33%) patients. The median overall survival is 26 (0.25-128) months; the median relapse-free survival is 17.5 (0-127) months. Conclusion: APL treatment in pregnant women, which is aimed at saving two lives, is effective and reasonable.
Databáze:	MEDLINE
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