Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice.

Autor: Huang J; 1] Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Filipe A; 1] Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] Unité Mixte de Recherche 995, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [3] Institut National de la Transfusion Sanguine (INTS), Paris, France., Rahuel C; 1] Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] Unité Mixte de Recherche 995, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [3] Institut National de la Transfusion Sanguine (INTS), Paris, France., Bonnin P; 1] Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] Service d'Exploration Fonctionnelles, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U965, Hôpital Lariboisière, Paris, France., Mesnard L; 1] Unité Mixte de Recherche 702, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [2] Université Pierre et Marie Curie, Sorbonne Universités, Paris, France., Guérin C; 1] Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Wang Y; 1] Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Le Van Kim C; 1] Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] Unité Mixte de Recherche 995, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [3] Institut National de la Transfusion Sanguine (INTS), Paris, France., Colin Y; 1] Université Paris Diderot, Sorbonne Paris Cité, Paris, France [2] Unité Mixte de Recherche 995, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [3] Institut National de la Transfusion Sanguine (INTS), Paris, France., Tharaux PL; 1] Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] Service de Néphrologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jazyk: angličtina
Zdroj: Kidney international [Kidney Int] 2014 May; Vol. 85 (5), pp. 1123-36. Date of Electronic Publication: 2014 Jan 15.
DOI: 10.1038/ki.2013.522
Abstrakt: Migration of circulating leukocytes from the vasculature into the surrounding tissue is an important component of the inflammatory response. Among the cell surface molecules identified as contributing to leukocyte extravasation is VCAM-1, expressed on activated vascular endothelium, which participates in all stages of leukocyte-endothelial interaction by binding to leukocyte surface expressed integrin VLA-4. However, not all VLA-4-mediated events can be linked to VCAM-1. A novel interaction between VLA-4 and endothelial Lutheran (Lu) blood group antigens and basal cell adhesion molecule (BCAM) proteins has been recently shown, suggesting that Lu/BCAM may have a role in leukocyte recruitments in inflamed tissues. Here, we assessed the participation of Lu/BCAM in the immunopathogenesis of crescentic glomerulonephritis. High expression of Lu/BCAM in glomeruli of mice with rapidly progressive glomerulonephritis suggests a potential role for the local expression of Lu/BCAM in nephritogenic recruitment of leukocytes. Genetic deficiency of Lu/BCAM attenuated glomerular accumulation of T cells and macrophages, crescent formation, and proteinuria, correlating with reduced fibrin and platelet deposition in glomeruli. Furthermore, we found a pro-adhesive interaction between human monocyte α4β1 integrin and Lu/BCAM proteins. Thus, Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury.
Databáze: MEDLINE
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