Intratympanic dexamethasone on cochlear blood flow in Guinea pigs.

Autor: Chiang RP; Department of Otolaryngology Head and Neck Surgery, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan ; Department of Otolaryngology Head and Neck Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan ; Sleep Technology Special Interest Group, Center of Innovation and Synergy for Intelligent Home Technology, National Taiwan University, No.95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan., Yeh CY; School of Public Health, Taipei Medical University Taiwan, 5 F Science Building, NO. 250, Wuxing Street, Xinyi District, Taipei City, 110 Taiwan, ROC., Chiang YC; Department of Otolaryngology, Taiwan Adventist Hospital, Taipei, Taiwan ; Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan., Lin KN; Department of Otolaryngology Head and Neck Surgery, Cardinal Tien Hospital, Hsintien, Taipei County, Taiwan ; Department of Otolaryngology Head and Neck Surgery, National Taiwan University Hospital, 362, Chung Cheng Road, Hsintien, Taipei County, 23137 Taiwan.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2013 Dec; Vol. 65 (Suppl 3), pp. 650-3. Date of Electronic Publication: 2012 Apr 25.
DOI: 10.1007/s12070-012-0552-3
Abstrakt: Unlabelled: To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15-20 min, followed by 20 min' recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups. Friedman Test was used to test the change of blood flow in these four timing. There were no significant changes of blood flow after injecting dexamethasone (p = .18 > .05) and normal saline (p = .93 > .05). The effects of dexamethasone on cochlear blood flow were variable and not significant. The following research would be designed under pathological conditions, such as cochlear ischemia, to show the possible mechanism of dexamethasone for specific inner ear disease.
Level of Evidence: 3a (SR of case-control studies).
Databáze: MEDLINE
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