[Estimation on the HIV-1 incidence among high risk groups using the pooling RNA technique].

Autor:	Dong LJ; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Chen M; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Su YZ; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Li JJ; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Zhang RZ; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Yang L; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Yang CJ; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Shi YH; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Chen HC; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Chen L; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Ma YL; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China., Jia MH; Center for AIDS/STD Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
Jazyk:	čínština
Zdroj:	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2013 Aug; Vol. 34 (8), pp. 812-4.
Abstrakt:	Objective: To timely identify the HIV-1 infection in window-period and to estimate the HIV-1 incidence among people who came for voluntary counseling and testing (VCT) service as well as men who have sex with men (MSM), respectively. Methods: HIV antibody negative samples that were determined by screening tests between January and October 2012, were collected and tested with pooling HIV-1 RNA testing technique (2-staged pooling by 50:1, 10:1). Positive cases were followed-up for HIV antibody testing while HIV incidence was calculated under Ron Brookmeyer' s method, among VCT and MSM populations. Results: Among 1400 HIV antibody negative samples of VCT, two showed HIV-1 RNA positive during the antibody window period with the HIV-1 incidence as 1.87% per year (95% CI: 1.23%-2.65% ). Among 500 HIV antibody negative samples from MSM population, two showed HIV-1 RNA positive in the antibody window period, with HIV-1 incidence as 5.31% per year (95% CI: 3.52%-7.45% ). Conclusion: Pooling HIV-1 RNA testing seemed a powerful tool for HIV antibody testing in the window-period. Measures should be taken to strengthen the HIV diagnostic programs among MSM and other high risk groups,during the HIV antibody window-period. More frequent detection approach as pooling HIV-1 RNA testing might be a good choice.
Databáze:	MEDLINE
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