1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.

Autor:	Mook-Kanamori DO; Department of Physiology and Biophysics (D.O.M.-K., J.R., N.A.Y., M.J.M.-K., W.A.A.M., K.S.) and Clinical Research Core (W.S.G., O.M.C., M.J.M.-K., S.A.K., C.M.), Weill Cornell Medical College, Qatar, Doha, Qatar; Department of Endocrinology (D.O.M.-K.), Leiden University Medical Centre, 2300 RC Leiden, The Netherlands; Departments of Dermatology (M.M.E.D.S., A.H.T., H.A.-H., K.A.S.A.-M., A.A.-O.) and Endocrinology (M.A.Z.), Hamad Medical Corporation, Doha, Qatar; Metabolon Inc (E.D.K.), Durham, North Carolina 27713; Unit of Periodontology (T.K.), Department of Restorative Dentistry, Periodontology, and Endodontology, University Medicine Greifswald, D-17487 Greifswald, Germany; and Institute of Bioinformatics and Systems Biology (K.S.), Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany., Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KA, Al-Obaidli A, Zirie MA, Rowe J, Yousri NA, Karoly ED, Kocher T, Sekkal Gherbi W, Chidiac OM, Mook-Kanamori MJ, Abdul Kader S, Al Muftah WA, McKeon C, Suhre K
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2014 Mar; Vol. 99 (3), pp. E479-83. Date of Electronic Publication: 2014 Jan 01.
DOI:	10.1210/jc.2013-3596
Abstrakt:	Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10(-13)). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studies have already established 1,5-AG in blood as a reliable marker of short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.
Databáze:	MEDLINE
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