Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial.

Autor: Berger PK; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Principe JL; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Laing EM; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Henley EC; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Pollock NK; Department of Pediatrics, Georgia Regents University, Augusta, GA, USA., Taylor RG; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Blair RM; Physicians Pharmaceuticals, Inc., Winston-Salem, NC, USA., Baile CA; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA., Hall DB; Department of Statistics, The University of Georgia, Athens, GA, USA., Lewis RD; Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA. Electronic address: rlewis@fcs.uga.edu.
Jazyk: angličtina
Zdroj: Nutrition research (New York, N.Y.) [Nutr Res] 2014 Jan; Vol. 34 (1), pp. 66-73. Date of Electronic Publication: 2013 Oct 22.
DOI: 10.1016/j.nutres.2013.09.005
Abstrakt: Human clinical trials targeted at preventing gains in body weight using soy protein and isoflavones are limited to adults and yield conflicting results. We hypothesized that daily intake of soy protein/isoflavones would attenuate gains in body weight to a greater extent than a casein-based control in 18 to 19 year-old females. To test this hypothesis, we conducted a randomized, double blind, placebo-controlled trial over 16 weeks to examine the effects of a soy protein/isoflavone-based meal replacement (experimental group) versus a casein-based meal replacement (control group) on body weight and body composition variables in female college freshmen (N = 120). Fat mass (FM), fat-free soft tissue mass (FFST), and percent body fat (%BF) were measured using dual energy X-ray absorptiometry (DXA; Delphi A). Repeated measures mixed models were used to determine the effects of treatment on anthropometric and body composition variables (body weight, waist circumference, FM, FFST, and %BF). No significant group×time interactions were observed, even when body mass index was controlled for in the analysis. Over 16 weeks, body weight, FM, FFST, and %BF significantly increased in both groups (P < .05). Our findings show that female college freshmen gained a significant amount of weight over the course of the 16-week study. Gains in body weight and FM were similar among participants assigned to the soy protein/isoflavone- and the casein-based meal replacements. Future research is warranted to determine the effects of soy protein/isoflavone- and casein-based meal replacements versus a non-intervention (i.e., non-protein based) control.
(© 2013.)
Databáze: MEDLINE
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