Cardiorespiratory effects induced by 2-nitrate-1,3-dibuthoxypropan are reduced by nitric oxide scavenger in rats.

Autor: Queiroz TM; Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil., Mendes-Júnior LG; Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil., Guimarães DD; Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil., França-Silva MS; Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil., Nalivaiko E; School of Biomedical Sciences and Pharmacy, University of Newcastle, NSW, Australia. Electronic address: Eugene.nalivaiko@newcastle.edu.au., Braga VA; Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil.
Jazyk: angličtina
Zdroj: Autonomic neuroscience : basic & clinical [Auton Neurosci] 2014 Apr; Vol. 181, pp. 31-6. Date of Electronic Publication: 2013 Dec 24.
DOI: 10.1016/j.autneu.2013.12.012
Abstrakt: The search for new nitric oxide donors is warranted by the limitations of organic nitrates currently used in cardiology. The new organic nitrate 2-nitrate-1,3-dibuthoxypropan (NDBP) exhibited promising cardiovascular activities in previous studies. The aim of this study was to investigate the cardiorespiratory responses evoked by NDBP and to compare them to the clinically used organic nitrate nitroglycerine (NTG). Arterial pressure, heart rate and respiration were recorded in conscious adult male Wistar rats. Bolus i.v. injection of NDBP (1 to 15mg/kg; n=8) and NTG (0.1 to 5mg/kg; n=8) produced hypotension. NDBP induced bradycardia at all doses, while NTG induced tachycardia at three lower doses but bradycardia at higher doses. Hydroxocobalamin (20mg/kg; HDX), a NO scavenger, blunted hypotension induced by NDBP (15mg/kg), and its bradycardic effect (n=6). In addition, HDX blunted both hypotension and bradycardia induced by a single dose of NTG (2.5mg/kg; n=6). Both NDBP and NTG altered respiratory rate, inducing a biphasic effect with a bradypnea followed by a tachypnea; HDX attenuated these responses. Our data indicate that NDBP and NTG induce hypotension, bradycardia and bradypnea, which are mediated by nitric oxide release.
(Copyright © 2013 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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