Isolated hepatitis B core antibody positive among vaccinated cohort in Malaysia.
| Autor: | Hudu SA, Malik YA, Niazlin MT, Harmal NS, Alshrari AS, Sekawi Z; Prof. Zamberi Sekawi, Medical Microbiology and Parasitology,, Faculty of Medicine and Health Sciences,, Universiti Putra Malaysia,, B-7-1, Kyvilla Apartment,, Jalan 5/5 Serdang Perdana, Selangor 43300, Malaysia, T: 60166225698, zamberi@upm.edu.my. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of Saudi medicine [Ann Saudi Med] 2013 Nov-Dec; Vol. 33 (6), pp. 591-4. |
| DOI: | 10.5144/0256-4947.2013.591 |
| Abstrakt: | Background and Objectives: Hepatitis B core antibodies (anti-HBc) are detected in almost every patient with previous exposure to hepatitis B virus (HBV). However, with this marker alone, one cannot understand the activity of the disease; therefore, this study aimed to identify the implication of isolated hepatitis B core antibody and evaluate the effect of hepatitis B vaccine booster in isolated anti-HBc among adults who received the HBV vaccine as infants. Design and Settings: A prospective cohort study of vaccinated undergraduate students of University Putra Malaysia. Patients and Methods: A total of 408 undergraduate students who received infant hepatitis B vaccination volunteered for this study; 5 mL of venous blood was taken from the volunteers. Hepatitis B surface antigen (HBsAg) and core antibodies were tested using a commercially available enzyme-linked immunosorbent assay kit according to the manufacturer's instructions (DRG international Inc., USA). Molecular detection of hepatitis B viral DNA was performed using nested polymerase chain reaction. Results: The prevalence of isolated anti-HBc among the vaccinated cohort was found to be 5.0%, out of which 80% had a hepatitis B surface antibodies (anti-HBs) titer higher than 10 IU/L, while 20% had less than 10 IU/L anti-HBs titer. All the anti-HBc positivesubjects had detectable hepatitis B viral DNA in their serum. Anamnestic response was found to be 100% among isolated anti-HBc with negative antibody. Conclusion: Isolated anti-HBc developed protective levels of anti-HBs after a single dose of recombinant hepatitis B vaccination. HBV DNA was detected in all isolated anti-HBc indicating occult chronic HBV infection with undetectable HBsAg. |
| Databáze: | MEDLINE |
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