Serial measurement of the circulating levels of tumour necrosis factor and its soluble receptors 1 and 2 for monitoring leprosy patients during multidrug treatment.

Autor:	Costa RD; Santa Casa de Misericórdia de Belo Horizonte, Belo HorizonteMG, Brasil., Mendonça VA; Laboratório de Inflamação e Metabolismo, Universidade Federal dos Vales do Jequitinhonha e Mucuri, DiamantinaMG, Brasil., Soriani FM; Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo HorizonteMG, Brasil., Lyon S; Universidade José do Rosário Vellano, AlfenasMG, Brasil., Penido RA; Hospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais, Belo HorizonteMG, Brasil., Costa AM; Universidade José do Rosário Vellano, AlfenasMG, Brasil., Costa MD; Santa Casa de Misericórdia de Belo Horizonte, Belo HorizonteMG, Brasil., Terra Fde S; Universidade Federal de Alfenas, AlfenasMG, Brasil., Teixeira MM; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo HorizonteMG, Brasil., Antunes CM; Santa Casa de Misericórdia de Belo Horizonte, Belo HorizonteMG, Brasil., Teixeira AL; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo HorizonteMG, Brasil.
Jazyk:	angličtina
Zdroj:	Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2013 Dec; Vol. 108 (8), pp. 1051-6.
DOI:	10.1590/0074-0276130240
Abstrakt:	Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae . The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT.
Databáze:	MEDLINE
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