Correlation between Plasma Adiponectin Levels and the Presence and Severity of Coronary Artery Disease.

Autor:	Amirzadegan A; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran., Shakarami A; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran., Borumand MA; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran., Davoodi G; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran., Ghaffari-Marandi N; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran., Jalali A; Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	The journal of Tehran Heart Center [J Tehran Heart Cent] 2013 Jul; Vol. 8 (3), pp. 140-5. Date of Electronic Publication: 2013 Jul 30.
Abstrakt:	Background: The existing evidence suggests that plasma adiponectin concentrations can be indicative of the presence and severity of coronary artery disease (CAD). However, the results of the studies conducted hitherto on this subject are inconsistent. We sought to investigate the possible correlation between plasma adiponectin levels and the presence and severity of CAD in patients undergoing non-urgent coronary angiography. Methods: In 399 consecutive patients undergoing non-urgent coronary angiography for CAD survey, plasma adiponectin, triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, and fasting blood sugar levels were measured and demographic characteristics such as age, sex, Body Mass Index, diabetes mellitus history, systemic hypertension history, and family history of CAD were collected. According to the angiography results, the patients were divided into two groups of CAD and non-CAD. The severity of coronary atherosclerosis in the CAD group was defined using the Gensini score system. Results: Average age was 61.4 ± 9.94 years in the CAD group and 57.9 ± 10.75 years in the non-CAD group. Also, 73.7% of the CAD group and 55.4% of the non-CAD group were male. Totally, 278 (69.7%) patients were found to have CAD. Patients without CAD did not have higher mean plasma adiponectin concentrations than did those with CAD (13.38 ± 11.96 vs. 14.95 ± 14.11 mcg/ml; p value = 0. 896). After adjustment for CAD conventional risk factors, plasma adiponectin levels still were not associated with CAD. No association was found between plasma adiponectin levels and the Gensini score. Furthermore, in contrast to the fairly strong correlation previously reported, there was no correlation between adiponectin levels and conventional CAD risk factors. Conclusion: We could not observe any relationship between plasma adiponectin concentrations and the presence or severity of CAD in patients undergoing coronary angiography.
Databáze:	MEDLINE
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