Efficacy and safety of hepatectomy performed with intermittent portal triad clamping with low central venous pressure.

Autor: Topaloglu S; Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Yesilcicek Calik K; Department of Nursing, School of Health Sciences, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Calik A; Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Aydın C; Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Kocyigit S; Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Yaman H; Department of Biochemistry, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Kutanis D; Department of Anesthesiology, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Karabulut E; Department of Biostatistics, School of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey., Dohman D; Department of Anesthesiology, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Orem A; Department of Biochemistry, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey., Arslan MK; Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 297971. Date of Electronic Publication: 2013 Dec 12.
DOI: 10.1155/2013/297971
Abstrakt: Background: This retrospective study was designed to investigate the efficacy and safety of intermittent portal triad clamping (PTC) with low central venous pressure (CVP) in liver resections.
Methods: Between January 2007 and August 2013, 115 patients underwent liver resection with intermittent PTC. The patients' data were retrospectively analyzed.
Results: There were 58 males and 57 females with a mean age of 55 years (± 13.7). Cirrhosis was found in 23 patients. Resections were performed for malignant disease in 62.6% (n = 72) and for benign disease in 37.4% (n = 43). Major hepatectomy was performed in 26 patients (22.4%). Mean liver ischemia period was 27.1 min (± 13.9). The mortality rate was 1.7% and the morbidity rate was 22.6%. Cumulative clamping time (t = 3.61, P < 0.001) and operation time (t = 2.38, P < 0.019) were significantly correlated with AST alterations (D-AST). Cumulative clamping time (t = 5.16, P < 0.001) was significantly correlated with D-ALT. Operation time (t = 5.81, P < 0.001) was significantly correlated with D-LDH.
Conclusions: Intermittent PTC under low CVP was performed with low morbidity and mortality. Intermittent PTC can be safely applied up to 60 minutes in both normal and impaired livers.
Databáze: MEDLINE
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