| Autor: |
Giniatullin RA, Shabunova IA, Nikol'skiĭ EE, Bukharaeva EA |
| Jazyk: |
ruština |
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1987 Jun; Vol. 103 (6), pp. 690-2. |
| Abstrakt: |
The mechanism of cholinolytic action of dipyroxime--reactivator of the phosphorylated acetylcholinesterase were investigated in the rat diaphragm muscle by voltage-clamp technique. Dipyroxime reduced the amplitude and prolonged the decay of the miniature end-plate currents (MEPC) without affecting its exponential nature. Current-voltage relationship exhibited negative conduction in the hyperpolarized region. Dipyroxime increased the voltage dependence of the time constant of MEPC decay (the membrane potential alteration necessary for e-fold change of the decay time constant reduced from 80 to 35 mV). It was concluded that dipyroxime is a very fast blocker of the open end-plate channels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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