Mycobacterium tuberculosis-specific CD8+ T cell recall in convalescing TB subjects with HIV co-infection.

Autor: Ongaya A; Kenya Medical Research Institute, Centre for Respiratory Diseases Research, Nairobi, Kenya., Huante MB; Departments of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA., Mwangi P; Kenya Medical Research Institute, Centre for Respiratory Diseases Research, Nairobi, Kenya., Keiser PH; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA., Amukoye E; Kenya Medical Research Institute, Centre for Respiratory Diseases Research, Nairobi, Kenya., Endsley JJ; Departments of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA; Department of Pathology, Institute for Human Infections and Immunity, Center for Tropical Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. Electronic address: jjendsle@utmb.edu.
Jazyk: angličtina
Zdroj: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2013 Dec; Vol. 93 Suppl, pp. S60-5.
DOI: 10.1016/S1472-9792(13)70012-X
Abstrakt: Memory T cell populations recover following phase I chemotherapy for tuberculosis (TB) and augment the effectiveness of antibiotics during the continuation phase of treatment. For those with human immunodeficiency virus (HIV), the CD8(+)T cells may have an especially important role in host defense to Mycobacterium tuberculosis (M.tb) as CD4(+)T cell function and/or numbers decline. Here we performed a preliminary study to investigate the impact of HIV infection status on CD8(+)T cell effector function during the convalescent TB period. Peripheral blood samples from convalescent HIV(+) and HIV(-) TB subjects were used to determine CD4(+)T cell count and monitor antigen-specific CD8(+) T cell activation of effector function (lymphoproliferation, IFN-γ, granulysin) in response to M.tb antigen. Our preliminary results suggest that HIV co-infection is associated with moderate suppression of the M.tb-specific memory CD8(+)T cell compartment in many subjects convalescent for TB. Interestingly, highly activated CD8(+)T cells were observed in recall experiments using peripheral blood from several HIV+ subjects that had low (<200 cells/mm(3)) CD4(+)T cell counts. Further investigation may provide important information for development of novel approaches to target M.tb-specific CD8(+)T cell memory to protect against TB in HIV-endemic regions.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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