| Autor: |
Khashaev ZKh, Grigor'ev PA |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 1987 Mar-Apr; Vol. 32 (2), pp. 347-8. |
| Abstrakt: |
Local anesthetics--cocaine, lidocaine, novocaine were tested for conductivity of bilayer lipid membranes containing anion-selective channels formed by polyene antibiotic amphotericin B. It has been shown that 5 X 10(-4) M cocaine doubles the membrane conductance. The line of efficiency of the tested anesthetics is: cocaine greater than lidocaine greater than novocaine. Possible molecular mechanism of the discovered effect is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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