Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia.

Autor:	Zhao Y; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Wang JW; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Tanaka T; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Hosono A; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Ando R; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Tokudome S; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Soeripto; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Triningsih FX; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Triono T; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Sumoharjo S; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Achwan EY; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Gunawan S; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China., Li YM; Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2013 Dec 14; Vol. 19 (46), pp. 8758-63.
DOI:	10.3748/wjg.v19.i46.8758
Abstrakt:	Aim: To investigate the correlation between the Helicobacter pylori (H. pylori) infection and host genetic background of healthy populations in Indonesia. Methods: In March 2007, epidemiological studies were undertaken on the general population of a city in Indonesia (Mataram, Lombok). The participants included 107 men and 187 women, whose ages ranged from 6 to 74 years old, with an average age of 34.0 (± 14.4) (± SD). The H. pylori of subject by UBT method determination, and through the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method parsing the single nucleotide polymorphism of interleukin (IL)-8, IL-4, IL-1β, CD14, tumor necrosis factor (TNF-α) and tyrosine-protein phosphates non-receptor type 11 (PTPN11) genotypes. The experimental data were analyzed by the statistical software SAS. Results: The H. pylori infection rates in the healthy Indonesian population studied were 8.4% for men and 12.8% for women; no obvious differences were noted for H. pylori infection rates by sex or age. TC genotypes of IL-4, TC and CC genotypes of TNF-α, and GA genotypes of PTPN11, were higher in frequency. Both CC and TC genotype of TNF-α T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of (OR = 1.99; 95%CI: 0.67-5.89) and (OR = 1.66; 95%CI: 0.73-3.76), respectively. C allele of IL-1β T-31C gene locus was at a higher risk (OR = 1.11; 95%CI: 0.70-1.73) of H. pylori infection, but no statistical significance was found in our study. Conclusion: We reveal that the association between the TNF-α and IL-1β genotypes may be the susceptibility of H. pylori in the studied population.
Databáze:	MEDLINE
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