No microsatellite instability using Bethesda panel and revised markers in uterine leiomyomas.

Autor: Hong JM; Department of Biological Sciences, Dartmouth College, Hanover, NH, USA., Lee JH, Gwon GJ, Kim DK
Jazyk: angličtina
Zdroj: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2014 Jan; Vol. 122 (1), pp. 1-4.
DOI: 10.1111/apm.12232
Abstrakt: Uterine leiomyomas are benign tumors of the uterus that arise clonally from smooth muscle cells of the myometrium and are very common reason for hysterectomy. The aim of this study was to evaluate microsatellite instability (MSI) in uterine leiomyomas using a set of MSI markers by Promega Corporation (Madison, WI, USA) and the Bethesda guideline. DNA was isolated from paired normal and tumoral tissues in 50 patients with uterine leiomyomas and MSI was analyzed by using seven microsatellite markers. Our result showed that microsatellite stability was found in all uterine leiomyomas. These data confirm the genetic status of uterine leiomyomas for the first time in Korean populations, and suggest that uterine leiomyomas have genetic stability in Korean.
(© 2013 APMIS. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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