The prognosis and treatment outcomes of patients with recurrent hepatocellular carcinoma after liver transplantation.

Autor: Roh YN; Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea., David Kwon CH, Song S, Shin M, Man Kim J, Kim S, Joh JW, Lee SK
Jazyk: angličtina
Zdroj: Clinical transplantation [Clin Transplant] 2014 Jan; Vol. 28 (1), pp. 141-8. Date of Electronic Publication: 2013 Dec 26.
DOI: 10.1111/ctr.12286
Abstrakt: Liver transplantation (LT) is performed in patients with hepatocellular carcinoma (HCC), but recurrent HCC after LT remains a problem. We retrospectively reviewed the data from 63 patients with recurrent HCC who underwent LT at a single institution between September 1996 and March 2011 to determine the prognosis of patients with recurrent HCC after LT. A survival analysis was performed with the preoperative data, histological findings, patterns of recurrence, and treatment methods. Univariate and multivariate analyses were performed to determine the factors associated with early (<1 yr) cancer-related death. The independent prognostic factors, according to the multivariate analysis, were recurrence within six months (hazards ratio [HR] = 4.557, p = 0.021) and initial multiple-organ involvement (HR = 5.494, p = 0.015). The survival rates of patients differed according to the treatment type. The combined treatment with local and systemic treatment resulted in increased survival even in patients with HCC recurrences involving multiple organs.
(© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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