Does an alkaline environment prevent the development of bisphosphonate-related osteonecrosis of the jaw? An experimental study in rats.

Autor: Dayisoylu EH; Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara and Konya, Turkey. Electronic address: edayisoylu@gmail.com., Üngör C; Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey., Tosun E; Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey., Ersöz S; Associate Professor, Department of Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey., Kadioglu Duman M; Associate Professor, Department of Pharmacology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey., Taskesen F; Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey., Senel FÇ; Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2014 Mar; Vol. 117 (3), pp. 329-34. Date of Electronic Publication: 2013 Nov 19.
DOI: 10.1016/j.oooo.2013.11.490
Abstrakt: Objective: To investigate the preventive effect of locally applied sodium bicarbonate on bisphosphonate-related osteonecrosis of the jaw (BRONJ).
Study Design: Thirty-six Sprague-Dawley rats were divided into 4 groups. Animals in group I received 0.1 mg/kg sterile saline 3 times per week for 8 weeks. Groups II, III, and IV received intraperitoneal zoledronate injection in the same manner with the same frequency and duration. The right first molar tooth was extracted in groups III and IV. One mL 8.4% sodium bicarbonate (SB) was applied to the extraction socket at the time of extraction in group IV. The effect of locally applied SB as an alkalizing agent was evaluated by histomorphometric analysis.
Results: BRONJ was observed in none of the animals in the control groups, 67% of the animals in the tooth extraction group, and none of the animals in the local SB application group (P < .01).
Conclusions: Administration of locally applied SB had positive effects on the prevention of BRONJ in animals, but further studies are required to verify the effectiveness of this form of treatment before its use in humans.
(Crown Copyright © 2014. Published by Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: