Nationwide inventory of risk factors for retinopathy of prematurity in the Netherlands.

Autor: van Sorge AJ; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: a.j.van_sorge@lumc.nl., Termote JU; Department of Neonatology, Wilhelmina Children's Hospital-University Medical Center, Utrecht, The Netherlands., Kerkhoff FT; Department of Ophthalmology, Maxima Medical Center, Veldhoven, The Netherlands., van Rijn LJ; Department of Ophthalmology, VU Medical Center, Amsterdam, The Netherlands., Simonsz HJ; Department of Ophthalmology, Sophia Children's Hospital-Erasmus MC, Rotterdam, The Netherlands., Peer PG; Department for Health Evidence, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Schalij-Delfos NE; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2014 Mar; Vol. 164 (3), pp. 494-498.e1. Date of Electronic Publication: 2013 Dec 19.
DOI: 10.1016/j.jpeds.2013.11.015
Abstrakt: Objectives: To study the incidence and risk factors for retinopathy of prematurity (ROP) in the Netherlands.
Study Design: Prospective, approximating population-based study that included infants with gestational age (GA) <32 weeks and/or birth weight (BW) <1500 g born in 2009. Pediatricians and ophthalmologists of all hospitals involved in care for premature infants reported data that were matched with the national perinatal database for risk factor analysis.
Results: Of 1380 infants, median GA 29.8 weeks (IQR 28.1-31.1) and median BW 1260 g (IQR 1020-1500), ROP developed in 21.9%. Logistic regression identified GA and BW as risk factors for ROP (P < .001). After adjustment for GA and BW, additional risk factors were inhaled nitric oxide (iNO; OR 2.6, 95% CI 1.1-6.2, P = .03), stay at a neonatal intensive care unit >28 days (OR 1.6, 95% CI 1.1-2.6, P = .03), and artificial ventilation >7 days (OR 1.6, 95% CI 1.1-2.5, P = .02). Prenatal glucocorticoids (OR 0.6, 95% CI 0.4-0.8, P < .001) and female sex (OR 0.7, 95% CI 0.5-0.99, P = .04) showed a lesser incidence of ROP. iNO remained significant after correction for all significant factors (OR 2.6, 95% CI 1.1-6.2, P = .03).
Conclusion: In addition to established risk factors (GA, BW, stay at a neonatal intensive care unit >28 days, and artificial ventilation >7 days), treatment with iNO as risk factor for ROP is a novel finding.
(Copyright © 2014 Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
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