(31) P MR spectroscopic imaging combined with (1) H MR spectroscopic imaging in the human prostate using a double tuned endorectal coil at 7T.

Autor: Luttje MP; Imaging Division, University Medical Center, Utrecht, Netherlands., Italiaander MG, Arteaga de Castro CS, van der Kemp WJ, Luijten PR, van Vulpen M, van der Heide UA, Klomp DW
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2014 Dec; Vol. 72 (6), pp. 1516-21. Date of Electronic Publication: 2013 Dec 19.
DOI: 10.1002/mrm.25070
Abstrakt: Purpose: Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both (1) H and (31) P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer.
Methods: A two-element (1) H/(31) P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two-element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. (1) H MRSI and (31) P MRSI were acquired in vivo in prostate cancer patients.
Results: The efficiency of the (1) H/(31) P coil is comparable to the dual channel (1) H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo (31) P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. (1) H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate.
Conclusion: (1) H MRSI and (31) P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for (1) H (quadrature) and (31) P (linear) without the need of cable traps and with negligible efficiency losses in the (1) H and (31) P channel.
(© 2013 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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