The awakening of DNA repair at Yale.

Autor: Hanawalt PC; Department of Biology, Stanford University, California.
Jazyk: angličtina
Zdroj: The Yale journal of biology and medicine [Yale J Biol Med] 2013 Dec 13; Vol. 86 (4), pp. 517-23. Date of Electronic Publication: 2013 Dec 13.
Abstrakt: As a graduate student with Professor Richard Setlow at Yale in the late 1950s, I studied the effects of ultraviolet and visible light on the syntheses of DNA, RNA, and protein in bacteria. I reflect upon my research in the Yale Biophysics Department, my subsequent postdoctoral experiences, and the eventual analyses in the laboratories of Setlow, Paul Howard-Flanders, and myself that constituted the discovery of the ubiquitous pathway of DNA excision repair in the early 1960s. I then offer a brief perspective on a few more recent developments in the burgeoning DNA repair field and their relationships to human disease.
Databáze: MEDLINE