| Autor: |
Mulcahy SP; Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02908, USA., Varelas JG; Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02908, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Tetrahedron letters [Tetrahedron Lett] 2013 Nov 27; Vol. 54 (48). |
| DOI: |
10.1016/j.tetlet.2013.09.108 |
| Abstrakt: |
The synthesis of β-carbolines is a mature field, yet new methods are desirable to introduce new functionality onto the core scaffold. We describe the incorporation of an additional fused ring onto the β-carboline via a novel palladium-catalyzed, one-pot Sonogashira coupling/intramolecular [2+2+2] cyclization. This method generates three rings in one flask and produces an annulated β-carboline in 80% yield. A preliminary mechanistic study into the sequence of events is described, which confirms an unprecedented catalytic role for palladium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect