| Autor: |
Kirvan CA; Department of Biological Sciences, California State University, Sacramento, CA, USA., Galvin JE, Hilt S, Kosanke S, Cunningham MW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2014 Mar; Vol. 7 (2), pp. 172-81. Date of Electronic Publication: 2013 Dec 18. |
| DOI: |
10.1007/s12265-013-9526-4 |
| Abstrakt: |
The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular domain of the streptococcal M5 protein were investigated. A repeat region peptides NT4, NT5/6, and NT7 induced valvulitis similar to the intact pepsin fragment of M5 protein. T cell lines from rats with valvulitis recognized M5 peptides NT5/6 and NT6. Passive transfer of an NT5/6-specific T cell line into naïve rats produced valvulitis characterized by infiltration of CD4+ cells and upregulation of VCAM-1, while an NT6-specific T cell line did not target the valve. Our new data suggests that M protein-specific T cells may be important mediators of valvulitis in the Lewis rat model of rheumatic carditis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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