Clinical profile, common thrombophilia markers and risk factors in 85 young Indian patients with arterial thrombosis.
| Autor: | Mishra MN; Department of Pathology, Dr. Lal Path Labs Pvt Ltd., New Delhi, India., Kalra R; Department of Cardiology, Indian Naval Hospital Ship Asvini, MumbaiMaharashtra, India., Rohatgi S; Department of Neurology, Command Hospital, ChandimandirHaryana, India. |
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| Jazyk: | angličtina |
| Zdroj: | Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2013; Vol. 131 (6), pp. 384-8. |
| DOI: | 10.1590/1516-3180.2013.1316369 |
| Abstrakt: | Context and Objective: Arterial thrombosis may occur consequent to hereditary thrombophilia and increased lipoprotein(a) [Lp(a)] and fibrinogen. Our aim was to study the prevalence of common thrombophilia markers in 85 consecutive cases of arterial thrombosis. Design and Setting: A retrospective study was conducted from 85 consecutive young patients treated as outpatients or admitted due to stroke or myocardial infarction at a tertiary care hospital. Methods: Eighty-five Indian patients (age < 45 years) presenting ischemic stroke (n = 48) or myocardial infarction (n = 37) and 50 controls were studied for seven thrombophilia markers including antithrombin (AT), factor V, protein C, protein S, activated protein C resistance (APC-R), fibrinogen and Lp(a). Functional assays for protein C, protein S, factor V and APC-R were performed using clotting-based methods. Semi-quantitative estimation of fibrinogen was done using Clauss's method and Lp(a) using immunoturbidimetry. Statistical analysis was done using the Epi Info 6 software. Results: Thirty-three samples (38.8%) tested positive for one or more thrombophilia markers. The three commonest abnormalities were elevated Lp(a) (20%), fibrinogen (17.6%) and low APC-R (14.2%). Low levels of protein C, protein S and AT were present in 4.7, 9.4 and 7% of the patients, respectively. Overall, the risk factor profile was: smoking (33%), positive family history (15.3%), hyperlipidemia (7%), hypertension, diabetes mellitus and obesity (2.3% each). Conclusions: An association was found between low levels of protein C, protein S and AT and arterial thrombosis, but only elevated fibrinogen levels, smoking, positive family history and hyperlipidemia showed statistical significance. |
| Databáze: | MEDLINE |
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