Pathology consultation on HbA(1c) methods and interferences.
| Autor: | Rhea JM; Dept of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Hospital Midtown, 550 Peachtree Ave NE, Davis Fischer Bldg, Room 1239, Atlanta, GA 30308; rjmolin@emory.edu., Molinaro R |
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| Jazyk: | angličtina |
| Zdroj: | American journal of clinical pathology [Am J Clin Pathol] 2014 Jan; Vol. 141 (1), pp. 5-16. |
| DOI: | 10.1309/AJCPQ23GTTMLAEVL |
| Abstrakt: | Objectives: To review the various hemoglobin (Hb) A1c methods, with a focus on interferences resulting from Hb variants. Methods: HbA1c is a marker used for the diagnosis and management of diabetes. Each available HbA1c method has advantages and challenges, such as its susceptibility to interferences. Results: The presence of Hb variants and/or abnormalities in RBC turnover cannot only interfere analytically with HbA1c measurements but also may affect the clinical interpretation of HbA1c values. Conclusions: Familiarity with the advantages and challenges of the various methods used for HbA1c testing is essential when establishing therapeutic management and goals based on HbA1c results, especially in populations with a high prevalence of Hb variants. |
| Databáze: | MEDLINE |
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