Evaluating the side effects of treatment for preterm labor in a center that uses "high-dose" magnesium sulfate.
| Autor: | Wilson MS; Department of Obstetrics and Gynecology, Granger Medical Clinic, West Jordan, Utah., Ingersoll M; Phoenix Perinatal Associates, Phoenix, Arizona., Meschter E; Department of Obstetrics and Gynecology, Good Samaritan Medical Center, Phoenix, Arizona., Bodea-Braescu AV; Phoenix Perinatal Associates, Phoenix, Arizona., Edwards RK; Department of Obstetrics and Gynecology, University of Alabama Birmingham School of Medicine, Birmingham, Alabama. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of perinatology [Am J Perinatol] 2014 Sep; Vol. 31 (8), pp. 711-6. Date of Electronic Publication: 2013 Dec 11. |
| DOI: | 10.1055/s-0033-1358770 |
| Abstrakt: | Objective: To evaluate the tolerability and safety of intravenous magnesium sulfate use for tocolysis in a center that uses a "high-dose" regimen. Study Design: We conducted a retrospective cohort study of patients treated with magnesium sulfate for preterm labor from December 2006 to June 2010. Data were abstracted from review of individual patient electronic medical records. Results: The cohort consisted of 456 women. Of these, 417 (91.4%) experienced side effects. Severe side effects (pulmonary edema, respiratory arrest, intensive care unit transfer, cardiac arrest, or death) occurred in 24 (5.3%) cases, all but one due to pulmonary edema. No cases of respiratory arrest, cardiac arrest, or death occurred. Those with severe side effects were less likely to have a singleton and more likely to have a higher order multifetal gestation (p < 0.001), received more magnesium, and more often were given multiple concurrent tocolytics (p = 0.04). Conclusion: "High-dose" magnesium tocolysis results in side effects for 9 of every 10 patients treated, and severe side effects occur in 1 of every 20 patients. When used for tocolysis, magnesium should be used as a single agent, for less than 48 hours, and with great caution in multifetal gestations. (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.) |
| Databáze: | MEDLINE |
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