Surfactant protein B gene polymorphism is associated with severe influenza.

Autor:	To KKW; State Key Laboratory for Emerging Infectious Diseases; Carol Yu Centre for Infection; Research Centre of Infection and Immunology; Department of Microbiology., Zhou J; Research Centre of Infection and Immunology; Department of Microbiology., Song YQ; Department of Biochemistry., Hung IFN; Carol Yu Centre for Infection; Research Centre of Infection and Immunology; Department of Medicine, The University of Hong Kong, Pokfulam., Ip WCT; Department of Microbiology., Cheng ZS; Department of Microbiology., Chan ASF; Department of Microbiology., Kao RYT; State Key Laboratory for Emerging Infectious Diseases; Research Centre of Infection and Immunology; Department of Microbiology., Wu AKL; Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong Special Administrative Region., Chau S; Department of Pathology, United Christian Hospital, Hong Kong Special Administrative Region., Luk WK; Department of Pathology, Tseung Kwan O Hospital, Hong Kong Special Administrative Region, China., Ip MSM; Department of Medicine, The University of Hong Kong, Pokfulam., Chan KH; Carol Yu Centre for Infection; State Key Laboratory for Emerging Infectious Diseases; Research Centre of Infection and Immunology; Department of Microbiology., Yuen KY; Department of Microbiology; Research Centre of Infection and Immunology; Carol Yu Centre for Infection; State Key Laboratory for Emerging Infectious Diseases. Electronic address: kyyuen@hku.hk.
Jazyk:	angličtina
Zdroj:	Chest [Chest] 2014 Jun; Vol. 145 (6), pp. 1237-1243.
DOI:	10.1378/chest.13-1651
Abstrakt:	Background: Surfactant proteins play a key role in alveolar stability. We examined whether single nucleotide polymorphisms (SNPs) related to the surfactant protein genes are associated with severe influenza. Methods: In the first cohort, 12 SNPs related to surfactant protein genes were compared between Chinese patients with severe and mild pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) infection who were matched for age, sex, and underlying risk conditions. The SNP rs1130866, which was significantly different between the two groups, was further genotyped in a second cohort of patients. Multivariate analysis was performed to control for confounding factors. The genotype frequencies were also compared with those of the general Han Chinese population. Results: This study consisted of 380 patients with A(H1N1)pdm09 infection. In the first cohort of 84 patients, the C allele of rs1130866, an SNP in the surfactant protein B gene (SFTPB), was significantly associated with severe disease (OR = 3.37, P = .0048), although the P value was .057 after Bonferroni correction. In the second cohort of 296 patients, the C/C genotype was confirmed in the univariate analysis to be associated with severe disease. Multivariate analysis of the second cohort showed that genotype C/C was an independent risk factor for severe A(H1N1)pdm09 infection (second cohort: OR = 2.087, P = .023). Compared to the general Han Chinese population, the C/C genotype was overrepresented in patients with severe A(H1N1)pdm09 infection (OR = 3.232, P = .00000056). Conclusions: SFTPB polymorphism is associated with severe influenza. The role of SFTPB in influenza warrants further studies.
Databáze:	MEDLINE
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