Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.

Autor: Dugas V; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Liston A; Autoimmune Genetics Laboratory, Department of Microbiology and Immunology, VIB and University of Leuven, Leuven, Belgium., Hillhouse EE; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Collin R; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Chabot-Roy G; Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada., Pelletier AN; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Beauchamp C; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Hardy K; Division of Biomedical Sciences, University of Canberra, Bruce, Canberra, Australia., Lesage S; 1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
Jazyk: angličtina
Zdroj: Genes and immunity [Genes Immun] 2014 Mar; Vol. 15 (2), pp. 82-7. Date of Electronic Publication: 2014 Jan 16.
DOI: 10.1038/gene.2013.65
Abstrakt: Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) coincide with at least some autoimmune disease susceptibility loci. Herein, we investigate the impact of major insulin-dependent diabetes (Idd) loci in defining the number of DN T cells. We demonstrate that although Idd3, Idd5 and Idd9 loci do not regulate DN T-cell number, NOD mice congenic for diabetes resistance alleles at the Idd13 locus show a partial restoration in DN T-cell number. Moreover, competitive and non-competitive bone marrow chimera experiments reveal that DN T-cell number is defined by a bone marrow-intrinsic, but DN T-cell-extrinsic, factor. This suggests that non-autonomous candidate genes define DN T-cell number in secondary lymphoid organs. Together, our results show that the regulation of DN T-cell number in NOD mice is at least partially conferred by alleles at the Idd13 locus.
Databáze: MEDLINE
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