New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.

Autor: Elkington BG; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: belkin3@uic.edu., Sydara K; Institute of Traditional Medicine, Vientiane, Lao PDR, Laos. Electronic address: kmnkong@gmail.com., Newsome A; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: anewso2@uic.edu., Hwang CH; Institute for Tuberculosis Research, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: chwang5@uic.edu., Lankin DC; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: lankindc@uic.edu., Simmler C; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: simmler@uic.edu., Napolitano JG; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: jgnapo@uic.edu., Ree R; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: rree@fieldmuseum.org., Graham JG; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: ucayali@uic.edu., Gyllenhaal C; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: gyllenha@uic.edu., Bouamanivong S; National Herbarium of Laos, Vientiane, Lao PDR, Laos. Electronic address: bsomsanith@gmail.com., Souliya O; Institute of Traditional Medicine, Vientiane, Lao PDR, Laos. Electronic address: onevilay@gmail.com., Pauli GF; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: gfp@uic.edu., Franzblau SG; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Institute for Tuberculosis Research, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: sgf@uic.edu., Soejarto DD; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Field Museum of Natural History, 1400 South Lake Shore Drive, Chicago, USA. Electronic address: dds@uic.edu.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2014 Feb 03; Vol. 151 (2), pp. 903-11. Date of Electronic Publication: 2013 Dec 11.
DOI: 10.1016/j.jep.2013.11.057
Abstrakt: Ethnopharmacological Relevance: There is widespread use of traditional herbal remedies in the Lao PDR (Laos). It is common practice to treat many diseases with local plants. This research project documented and analysed some of these traditional remedies used to treat symptoms of tuberculosis (TB).
Materials and Methods: This research was executed by interviewing healers about plants used traditionally to treat the symptoms of TB. Samples of some of the plants were collected, and extracts of 77 species were submitted to various in vitro assays in order to determine the amount of growth inhibition of virulent Mycobacterium tuberculosis H37Rv (Mtb), as opposed to other microbes and mammalian Vero cells.
Results: Interviews took place with 58 contemporary healers in 5 different provinces about plants currently used, giving a list of 341 plants. Bioassay-guided fractionation was performed on Marsypopetalum modestum (Pierre) B. Xue and R.M.K. Saunders (Annonaceae), leading to the isolation of dipyrithione, an anti-mycobacterial compound isolated for the first time from the genus Marsypopetalum through this research.
Conclusions: This research has helped to increase awareness of Laos' rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries.
(© 2013 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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