Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis.

Autor: Rondón C; Allergy Service, Carlos Haya Hospital, Malaga, Spain. Electronic address: carmenrs61@gmail.com., Campo P; Allergy Service, Carlos Haya Hospital, Malaga, Spain., Zambonino MA; Allergy Service, Carlos Haya Hospital, Malaga, Spain., Blanca-Lopez N; Allergy Service, Infanta Leonor Hospital, Madrid, Spain., Torres MJ; Allergy Service, Carlos Haya Hospital, Malaga, Spain., Melendez L; Research Laboratory, Carlos Haya Hospital-Fundacion IMABIS, Malaga, Spain., Herrera R; Research Laboratory, Carlos Haya Hospital-Fundacion IMABIS, Malaga, Spain., Guéant-Rodriguez RM; Inserm U 954 Nutrition-Génétique-Exposition aux risques environnementaux, Faculté de Médecine Nancy, Vandoeuvre les Nancy, Nancy, France., Guéant JL; Inserm U 954 Nutrition-Génétique-Exposition aux risques environnementaux, Faculté de Médecine Nancy, Vandoeuvre les Nancy, Nancy, France., Canto G; Allergy Service, Infanta Leonor Hospital, Madrid, Spain., Blanca M; Allergy Service, Carlos Haya Hospital, Malaga, Spain.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2014 Apr; Vol. 133 (4), pp. 1026-31. Date of Electronic Publication: 2013 Dec 13.
DOI: 10.1016/j.jaci.2013.10.034
Abstrakt: Background: Local allergic rhinitis (LAR) is a common disease that affects 25.7% of the rhinitis population and more than 47% of patients previously diagnosed with nonallergic rhinitis. Whether LAR is the first step in the natural history of allergic rhinitis (AR) with systemic atopy or a consistent entity is unknown.
Objective: The aim was to evaluate the natural history of a population with LAR of recent onset and the development of AR and asthma.
Methods: A prospective 10-year follow-up study with initial cohorts of 194 patients with LAR of recent onset and 130 healthy controls is being undertaken. A clinical-demographic questionnaire, spirometry, skin prick test, and specific IgE to aeroallergens were done yearly. Nasal allergen provocation tests with Dermatophagoides pteronyssinus, Alternaria alternata, Olea europea, and a mix of grass pollen were performed at baseline and after 5 years.
Results: At disease onset, most of the patients with LAR had moderate-to-severe persistent-perennial rhinitis; conjunctivitis and asthma were the main comorbidities (51.1% and 18.8%, respectively), and D pteronyssinus was the most relevant aeroallergen (51.1%). After 5 years of follow-up, a worsening of rhinitis was detected in 26.2%, with an increase in symptom persistence and severity, and new associations with conjunctivitis and asthma. Atopy was detected by skin prick test and/or serum specific-IgE in patients with LAR (6.81%) and in controls (4.5%).
Conclusions: This study shows a similar rate of development of systemic atopy in LAR and controls, which suggests that LAR is an entity well differentiated from AR. To determine the natural course of LAR more precisely, this study is in progress to complete 10 years of follow-up.
(Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: