Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study.
| Autor: | Gilaberte Y; 1 Unit of Dermatology, Hospital San Jorge , Huesca, Spain ., Aspiroz C, Alejandre MC, Andres-Ciriano E, Fortuño B, Charlez L, Revillo MJ, Hamblin MR, Rezusta A |
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| Jazyk: | angličtina |
| Zdroj: | Photomedicine and laser surgery [Photomed Laser Surg] 2014 Jan; Vol. 32 (1), pp. 54-7. Date of Electronic Publication: 2013 Dec 13. |
| DOI: | 10.1089/pho.2013.3590 |
| Abstrakt: | Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case Report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix(®))-PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response. |
| Databáze: | MEDLINE |
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