Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.

Autor: Ramírez-Sandoval JC; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Vasco de Quiroga 15, Mexico City , Mexico and., Barrera-Chimal J, Simancas PE, Rojas-Montaño A, Correa-Rotter R, Bobadilla NA, Morales-Buenrostro LE
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2014 Feb; Vol. 19 (1), pp. 63-9. Date of Electronic Publication: 2013 Dec 11.
DOI: 10.3109/1354750X.2013.867536
Abstrakt: Objective: Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).
Methods: Biomarkers were measured in 67 KTR with AKI caused by different entities.
Results: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.
Databáze: MEDLINE
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