| Autor: |
Stakhneva EM; Research Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. stahneva@yandex.ru., Vavilin VA, Ragino YI, Safronova OG, Shintyapina AB, Ivanova MV |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Nov; Vol. 156 (1), pp. 63-5. |
| DOI: |
10.1007/s10517-013-2278-y |
| Abstrakt: |
Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with glycyrrhizic acid (atorvaglyzin and simvaglyzin). The amount of 3-hydroxy-3-methyl-glutaryl-CoA reductase protein in rats decreased by 13 and 25% (p<0.05) 24 h after treatment with atorvaglyzin and simvaglyzin, respectively. Activity of this enzyme decreased by 46% in rats treated with atorvaglyzin. The amount of messenger RNA in these groups significantly increased as compared to control group (untreated animals). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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